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中药注射剂的类过敏反应及其风险防控
梁爱华, 易艳, 张宇实, 韩佳寅, 田婧卓, 卢禹婷, 冯筱懿, 李春英
中国药学杂志 ›› 2015, Vol. 50 ›› Issue (15) : 1301-1308.
PDF(1460 KB)
PDF(1460 KB)
中药注射剂的类过敏反应及其风险防控
Pseudoallergic Reactions of Traditional Chinese Medicine Injections and the Approaches for Risk Prevention and Control
中药注射剂报道最多的不良反应是“过敏反应”,其症状包括皮肤黏膜红肿、瘙痒;腹痛、恶心;胸闷、呼吸困难以及血压下降等,严重时可发生休克或死亡。笔者通过对中药注射剂临床不良反应特点以及临床前实验研究结果的分析,提出中药注射剂的不良反应主要是以类过敏反应为主的观点。类过敏反应与过敏反应性质和产生机制不同,二者不宜混淆,否则会对临床应采取的处理措施以及基础研究方向产生误导。笔者还探讨了中药注射剂类过敏反应(PARs)风险防控途径。
Allergic hypersensitivity reactions (AHRs) are the most commonly reported adverse reactions of traditional Chinese medicine injections, mainly including skin and mucosa redness, itching, abdominal pain, chest tightness, dyspnea and nausea, blood pressure decline, with clinical symptoms, and even shock or death In this paper, we analyzed the characteristics of clinical adverse reactions and preclinical study results of traditional Chinese medicine injections, and proposed a view of point that the main adverse reactions of traditional Chinese medicine injections are nonallergic hypersensitivity reactions (NHRs) or pseudoallergic reactions (PARs) instead of real AHRs Because there are absolute differences in the characteristics and the pathogenesis mechanisms between PARs and AHRs, they should not be confused, otherwise, the clinical processing measures and the direction of basic research on the adverse reactions of traditional Chinese medicine injections would be misleading This paper also discussed the approaches for risk prevention and control of PARs of traditional Chinese medicine injections.
中药注射剂 / 类过敏反应 / 过敏样反应 / 动物模型 / 不良反应 {{custom_keyword}} /
Chinese medicine injection / pseudoallergic reaction / anaphylactoid reaction / animal model / adverse reaction {{custom_keyword}} /
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国家重大新药创制专项(2015ZX09501004);国家自然科学基金资助项目(81374057);中国中医科学院自主选题(2014年)
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